DIGITAL PATHOLOGY GROUNDED IN REALITY
Validate | Standardise | Manage
Take control of colour calibration to ICC profiles
Enhance the accuracy of your scanners and the digital images they produce by colour calibrating them to a unique industry standard ICC profile.
Train and run your digital pathology AI software using accurate, quality data that reflects ground truth colour – regardless of scanner used or device manufacturer.
Ensure time-to-market efficiency for new pharmaceuticals by ensuring stringent and competitive GLP, whilst maintaining ROI for current WSI infrastructure.
Understand the colour performance of your installed digital pathology devices. Ensure decisions and workflow are based on ground-truth data.
Advancements in digital pathology and Artificial Intelligence are positively impacting patient outcomes; from a reduction in waiting times for results and treatments to a faster time-to-market for new pharmaceuticals. However, now more than ever, it is vital that decisions are based on quality data – colour fidelity is critical.
In this webinar we will highlight the importance of validating and standardising the colour of digital images produced by WSI devices; share the latest thinking on how to ensure colour fidelity within your digital pathology workflow; introduce and demonstrate our seamless Sierra VSA solution, which lets you see how your individual devices reproduce colour; and finally share real-world data on the positive impact Sierra is having in a range of digital pathology environments.
Colour calibration and standardisation is complex. A significant degree of variation in colour exists between different whole slide imaging (WSI) systems and even two WSI of the same type. This can be induced by variations in the optical paths and the digital interpretation of light that create the images. In addition, the method by which WSI systems observe colour is different from the way the human eye does, thus images need to be corrected for to account for these differences.
To address these challenges FFEI have developed the Sierra colour calibration product portfolio. Together they correct digital colour using a unique biologically-stained slide-based device and ICC colour profile to recreate ‘ground-truth’ colour.
Measuring and calibrating WSI devices not only boosts pathologist confidence, but also has positive implications on the development of high-accuracy digital pathology AI software, as all data is standardised to reality.
Sierra Colour Calibration slide with uniquely stained bio-polymer covers the full range of pathology stains used.
Sierra seeks to ensure colour fidelity throughout the imaging process. The goal of this is to provide confidence that the colour is representative of the ‘true colour’ of the tissue sample and not digitally altered by the scanning process. This provides a guarantee that either a pathologist, analyst or AI software is working from ground-truth data.
Whilst this means that all WSI scanner colour outputs can be uniformly generated for universally matched colour data, it also means that human or AI decisions are based upon real colour data, no longer compromised by digitisation.
Many factors can impact on the accuracy of AI. Inconsistencies will reduce AI ability to categorise/quantify information and therefore make appropriate, accurate decisions.
In the case of digital pathology AI software, the potential impact is at best a delayed diagnosis and at worst a misdiagnosis, which may lead to ineffective treatment being given with life changing, even life limiting, consequences.
The different colour densities present in precisely and selectively stained human tissue are critical to accurate diagnosis. There is an elementary need to not just train AI software to recognise shapes, but to ensure ongoing accuracy of input data and decision-making reliability. This means the colour of digital images across WSI device types must be consistent and standards-based.
The Sierra Colour Calibration Portfolio comprises of three core products, with the opportunity to engage FFEI’s professional services team for bespoke development and integration work.
Our patented colour reference slide
The slide carries 55 patches of a specialist material that mimics human tissue binding histological stains, to generate the ground truth colour of pathology. This enables the colour error of a scanner to be measured for validation and calibrated to ‘real-life’ colour data for accurate standardisation.
Analyse the colour reproducibility of your DP scanner
A comprehensive package consisting of a Sierra slide and specialist software application to analyse and validate a WSI device’s current colour characteristics, for comparison to the ground truth colour and standardisation achievable by Sierra technology across your scanner portfolio.
Device specific ICC profile generation
Used in combination with the Sierra slide and VS Analyser software, Sierra VS Profiler enables a unique ICC profile to be generated to standardise the colour of the digital images produced, to ground-truth colour
Integration into your workflow
Whether you are a manufacturer looking to ensure ICC grade colour reproducibility from the point of production, or a pharmaceutical looking to standardise your portfolio of devices, we have the expertise to fully integrate Sierra into your workflow.
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